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Vitiligo
Reviewed by Medicinsk Expert•Last updated: 2026-10-22•Condition

Vitiligo

Vitiligo is a common condition characterized by patchy loss of skin and hair pigmentation, often progressing over time and considered an autoimmune disorder where the immune system attacks melanocytes.

Overview

Vitiligo is a condition that causes patchy loss of skin coloring (pigmentation). In addition, hair on these regions of skin can also lose pigment and appear white. The average age of onset of vitiligo is in the mid-twenties, but it can appear at any age. The size and number of patches varies from person to person. The condition tends to progress over time, with larger areas of the skin losing pigment. However, the patches can remain stable or even improve in some affected individuals.

Researchers have identified several forms of vitiligo. Generalized vitiligo (also called nonsegmental vitiligo), which is the most common form, involves loss of pigment (depigmentation) in many areas of the body. Depigmentation typically occurs on the face, neck, and scalp, and around body openings such as the mouth and genitals. Sometimes pigment is lost in mucous membranes, such as the lips. Loss of pigmentation is also frequently seen in areas that tend to experience rubbing, impact, or other trauma, such as the hands, arms, and places where bones are close to the skin surface (bony prominences). Another form of the condition, called segmental vitiligo, is associated with smaller patches of depigmented skin that appear on one side of the body in a limited area. This form occurs in about 10 percent of affected individuals.

Vitiligo is generally considered to be an autoimmune disorder. Autoimmune disorders occur when the immune system attacks the body's own tissues and organs. In people with vitiligo the immune system appears to attack the melanocytes. About 15 to 25 percent of people with vitiligo are also affected by at least one other autoimmune disorder, particularly autoimmune thyroid disease, rheumatoid arthritis, type 1 diabetes, psoriasis, pernicious anemia, Addison disease, systemic lupus erythematosus, celiac disease, Crohn's disease, or ulcerative colitis.

In the absence of other autoimmune conditions, vitiligo does not affect general health or physical functioning. However, concerns about appearance and ethnic identity are significant issues for many affected individuals.

Frequency

Vitiligo is a common disorder, affecting between 0.5 percent and 1 percent of the population worldwide. However, many cases may not be reported, and some researchers suggest the condition may affect up to 1.5 percent of the population. While the condition may be more noticeable in dark-skinned people, it occurs with similar frequency in all ethnic groups.

Causes & Risk Factors

Variations in over 30 genes, occurring in different combinations, have been associated with an increased risk of developing vitiligo. Two of these genes are NLRP1 and PTPN22. The NLRP1 gene provides instructions for making a protein that is involved in the immune system, helping to regulate the process of inflammation. Inflammation occurs when the immune system sends signaling molecules and white blood cells to a site of injury or disease to fight microbial invaders and facilitate tissue repair. The body then stops (inhibits) the inflammatory response to prevent damage to its own cells and tissues.

The PTPN22 gene provides instructions for making a protein involved in signaling that helps control the activity of immune system cells called T cells. T cells identify foreign substances and defend the body against infection.

The variations in the NLRP1 and PTPN22 genes that are associated with an increased risk of developing vitiligo likely affect the activity of the NLRP1 and PTPN22 proteins, making it more difficult for the body to control inflammation and prevent the immune system from attacking its own tissues.

Studies indicate that variations in a number of other genes also affect the risk of vitiligo. Many of these genes are also involved in immune system function or melanocyte biology, and variations in each likely make only a small contribution to vitiligo risk. Some of the gene changes associated with an increased risk of vitiligo have also been associated with an increased risk of other autoimmune conditions.

It is unclear what specific circumstances trigger the immune system to attack melanocytes in the skin. Research suggests that the immune system of affected individuals may react abnormally to melanocytes that are stressed by factors such as chemicals or ultraviolet radiation. In addition, the melanocytes of people with vitiligo may be more susceptible to stress than those of the general population and therefore may be more likely to be attacked by the immune system.

The condition probably results from a combination of genetic and environmental factors, many of which have not been identified. Studies suggest that psychological stress, exposure to ultraviolet radiation, or contact with certain chemicals or skin-whitening products may trigger vitiligo in predisposed individuals.

Associated Genes

  • NLRP1
  • PTPN22

Inheritance Pattern

Vitiligo sometimes runs in families, but the inheritance pattern is complex because multiple causative factors are involved. About one-fifth of people with this condition have at least one close relative who is also affected.

Other Names

Additional Information & Resources

Patient Support and Advocacy Resources

  • National Organization for Rare Disorders (NORD)

Clinical Trials

  • ClinicalTrials.gov

Catalog of Genes and Diseases from OMIM

  • VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1; VAMAS1
  • VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 6; VAMAS6

Scientific Articles

  • PubMed

References

  • Boissy RE, Spritz RA. Frontiers and controversies in the pathobiology of vitiligo: separating the wheat from the chaff. Exp Dermatol. 2009 Jul;18(7):583-5. doi: 10.1111/j.1600-0625.2008.00826.x. Epub 2009 Mar 6. Citation on PubMed or Free article on PubMed Central
  • Halder RM, Chappell JL. Vitiligo update. Semin Cutan Med Surg. 2009 Jun;28(2):86-92. doi: 10.1016/j.sder.2009.04.008. Citation on PubMed
  • Jin Y, Birlea SA, Fain PR, Ferrara TM, Ben S, Riccardi SL, Cole JB, Gowan K, Holland PJ, Bennett DC, Luiten RM, Wolkerstorfer A, van der Veen JP, Hartmann A, Eichner S, Schuler G, van Geel N, Lambert J, Kemp EH, Gawkrodger DJ, Weetman AP, Taieb A, Jouary T, Ezzedine K, Wallace MR, McCormack WT, Picardo M, Leone G, Overbeck A, Silverberg NB, Spritz RA. Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. Nat Genet. 2012 May 6;44(6):676-80. doi: 10.1038/ng.2272. Citation on PubMed or Free article on PubMed Central
  • Jin Y, Birlea SA, Fain PR, Gowan K, Riccardi SL, Holland PJ, Mailloux CM, Sufit AJ, Hutton SM, Amadi-Myers A, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taieb A, Jouary T, Ezzedine K, van Geel

Frequently Asked Questions

Currently, there is no scientific evidence that a specific diet or nutritional supplement can stop or reverse vitiligo progression. While some patients report benefits from antioxidants or vitamin D, these are not proven treatments for the condition itself. However, maintaining a balanced diet supports overall immune system health. Patients should be cautious with unproven herbal remedies or high-dose supplements, as they may interact with prescribed medications or cause side effects. It is always best to consult with a dermatologist before starting any new supplement regimen.
Vitiligo can cause hair in affected areas, including the scalp, eyebrows, and beard, to turn white or gray due to the loss of pigment-producing cells in the hair follicles. This change is usually permanent for the specific hair shaft that has already grown out, but new hair growth may retain normal pigment if the follicle's melanocytes recover. There is no specific treatment to reverse white hair caused by vitiligo, but camouflage techniques such as hair dyes or eyebrow pencils can be used. If hair loss occurs in the affected area, it is typically non-scarring, meaning hair may regrow, though it may remain depigmented.
Because depigmented skin lacks melanin, it is significantly more susceptible to UV damage and sunburn. Patients should use a broad-spectrum sunscreen with an SPF of 30 or higher on all exposed skin, including the white patches. Applying sunscreen to both pigmented and non-pigmented areas helps minimize the visual contrast between the two. Additionally, wearing protective clothing, such as long-sleeved shirts, wide-brimmed hats, and UV-blocking sunglasses, is recommended. Regular reapplication of sunscreen every two hours, or immediately after swimming or sweating, is essential for adequate protection.
Yes, a phenomenon known as the Koebner effect can cause vitiligo patches to appear at sites of skin injury, such as cuts, scrapes, sunburns, or areas of chronic friction. To minimize this risk, patients should avoid tight-fitting clothing that rubs against the skin, such as tight bras, waistbands, or socks. It is also important to handle skin gently during shaving or exfoliation and to treat any cuts or abrasions promptly to prevent infection and inflammation. Avoiding harsh chemicals and abrasive scrubbing on the skin can also help reduce the likelihood of triggering new depigmentation.
Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.

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