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IL17RC gene

Reviewed by Medicinsk Expert•Last updated: 2026-10-22•Gene

IL17RC gene

The IL17RC gene provides instructions for a receptor protein that is essential for the immune system's defense against Candida fungal infections.

Normal Function

The IL17RC gene provides instructions for making a protein involved in the body's defense against the fungus Candida. When the immune system recognizes Candida, it generates Th17 cells, which produce signaling molecules called the interleukin-17 (IL-17) family. This process, known as the IL-17 pathway, triggers the release of cytokines and white blood cells to fight invaders, promote tissue repair, and stimulate the production of antimicrobial peptides that control Candida growth on mucous membranes.

The protein produced from the IL17RC gene functions as part of a receptor for IL-17 cytokines. By working with the protein produced from the IL17RA gene, it allows IL-17 cytokines to attach to cells, triggering signals that promote inflammation and immune defense.

Health Conditions Related to Genetic Changes

Familial candidiasis

Mutations in the IL17RC gene have been identified in people with familial candidiasis, an inherited tendency to develop Candida infections. Most affected individuals experience chronic yeast infections of the skin, nails, and mucous membranes, known as chronic mucocutaneous candidiasis, beginning in early childhood.

These mutations result in an absence of the IL17RC receptor protein, which impairs IL-17 signaling. This reduction in signaling decreases the production of antimicrobial peptides and inflammatory molecules, leading to the chronic infections characteristic of this condition.

Genomic Location

The IL17RC gene is found on chromosome 3.

Frequently Asked Questions

Management focuses on aggressive antifungal therapy (topical or systemic), regular skin care, and monitoring for complications. Some patients benefit from biologic agents that boost IL‑17 signaling, such as IL‑17A inhibitors, but these are used cautiously because they can worsen infections. Regular follow‑up with an infectious disease specialist is essential.
Yes, first‑degree relatives can be screened with the same genetic test. A positive result indicates a 50 % chance of inheriting the mutation. If a carrier, they may develop mild or no symptoms but should be monitored for early signs of candidiasis, especially during pregnancy or immunosuppression.
targeted next‑generation sequencing panel that includes IL17RC can identify pathogenic variants. If a mutation is suspected, a confirmatory Sanger sequencing of the specific exon is often performed. The test is usually ordered by a geneticist or immunologist after a detailed clinical evaluation.
Good hygiene, keeping skin dry, avoiding prolonged use of topical steroids, and promptly treating any skin breaks can lower infection risk. Some patients find that a low‑sugar diet and probiotic supplementation help maintain a healthy mucosal microbiome, though evidence is limited.===
Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.