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SLCO1B1 gene
Reviewed by Medicinsk Expert•Last updated: 2026-10-22•Gene

SLCO1B1 gene

The SLCO1B1 gene provides instructions for a protein that transports substances like bilirubin and certain medications into the liver for clearance from the body.

Normal Function

The SLCO1B1 gene provides instructions for making a protein called organic anion transporting polypeptide 1B1, or OATP1B1. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body. For example, the OATP1B1 protein transports bilirubin, which is a yellowish substance that is produced when red blood cells are broken down. In the liver, bilirubin is dissolved in a digestive fluid called bile and then excreted from the body. The OATP1B1 protein also transports certain hormones, toxins, and drugs into the liver for removal from the body. Drugs transported by the OATP1B1 protein include statins, which are used to treat high cholesterol; heart disease medications; certain antibiotics; and some drugs used for the treatment of cancer.

Health Conditions Related to Genetic Changes

Rotor syndrome

Mutations in the SLCO1B1 gene are involved in Rotor syndrome. This condition is characterized by elevated levels of bilirubin in the blood that can cause yellowing of the skin and whites of the eyes (jaundice). For this condition to occur, individuals must have mutations in the SLCO1B1 gene and a related gene called SLCO1B3. This related gene provides instructions for making a protein called OATP1B3, which has a similar transport function to OATP1B1. In some cases, the condition is caused by a deletion of genetic material that removes parts of both the SLCO1B1 and SLCO1B3 genes, so no functional OATP1B1 or OATP1B3 protein is made. Most mutations that cause Rotor syndrome lead to abnormally short, nonfunctioning OATP1B1 and OATP1B3 proteins. Without the function of either transport protein, bilirubin is less efficiently taken up by the liver and cleared from the body. The buildup of this substance leads to jaundice in people with Rotor syndrome.

Other disorders

Certain common variations (polymorphisms) in the SLCO1B1 gene are associated with a reduced ability to process certain drugs, including statins. The most widely studied polymorphism associated with this abnormality, which is found in approximately 15 percent of the population, changes a single protein building block in the OATP1B1 protein: the amino acid valine at position 174 is replaced with the amino acid alanine (written as V174A or SLCO1B1*5). The protein produced from this version of the SLCO1B1 gene is less able to transport compounds into the liver, which leads to elevated levels of the compounds in the body.

When statins are not efficiently transported into the liver, they build up in the body, and can cause a condition known as statin-induced myopathy. This condition causes fatigue, pain, tenderness, weakness, and cramping in muscles. People with the V174A polymorphism who take statin drugs have an increased risk of developing statin-induced myopathy.

Other Names for This Gene

  • HBLRR
  • liver-specific organic anion transporter 1
  • LST-1
  • LST1
  • OATP-2
  • OATP-C
  • OATP1B1
  • OATP2
  • OATPC
  • SLC21A6
  • SO1B1_HUMAN
  • sodium-independent organic anion-transporting polypeptide 2
  • solute carrier family 21 (organic anion transporter), member 6
  • solute carrier family 21 member 6
  • solute carrier organic anion transporter family, member 1B1

Genomic Location

The SLCO1B1 gene is found on chromosome 12.

Frequently Asked Questions

The main sign of Rotor syndrome is jaundice, which is a yellowing of the skin and the whites of the eyes, caused by elevated levels of bilirubin in the blood. While often mild and not associated with severe health problems, persistent or worsening jaundice, especially if accompanied by other unusual symptoms, should prompt a medical evaluation to confirm the diagnosis and rule out other conditions.
Rotor syndrome is generally considered a benign condition, meaning it does not typically lead to severe liver damage or require specific treatment. Management primarily involves monitoring bilirubin levels and avoiding medications that could worsen jaundice or are cleared by the OATP1B1/OATP1B3 proteins. Individuals with Rotor syndrome usually have a normal life expectancy and do not experience significant long-term health complications beyond the intermittent jaundice.
mutation in the SLCO1B1 gene can impair the OATP1B1 protein's ability to transport certain medications, like statins (used for high cholesterol), into the liver for clearance. This can lead to higher levels of these drugs in the bloodstream, potentially increasing the risk of side effects. It's crucial to inform your doctor about your SLCO1B1 gene status so they can adjust medication dosages or choose alternative drugs if necessary.
Rotor syndrome is inherited in an autosomal recessive pattern, meaning a person must inherit two mutated copies of the SLCO1B1 and SLCO1B3 genes (one from each parent) to develop the condition. If you are a carrier (have one mutated copy) and your partner is also a carrier, there is a 25% chance with each pregnancy that your child will inherit two mutated copies and develop Rotor syndrome, a 50% chance they will be a carrier, and a 25% chance they will not inherit any mutated copies.
Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.

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