SNCB gene
The SNCB gene provides instructions for making the beta-synuclein protein, which is thought to play a role in learning, memory, and the protection of nerve cells.
Normal Function
The SNCB gene provides instructions for making a protein called beta-synuclein. While its exact function is unknown, it is likely involved in synaptic plasticity—the ability of connections between nerve cells (synapses) to change and adapt over time in response to experience, a process critical for learning and memory. Beta-synuclein may also prevent the harmful accumulation of a similar protein called alpha-synuclein in nerve cells (neurons).
Health Conditions Related to Genetic Changes
Dementia with Lewy bodies
At least two mutations in the SNCB gene have been found to cause dementia with Lewy bodies. This condition is characterized by intellectual decline (dementia), visual hallucinations, sudden changes in attention and mood, and movement problems such as rigidity of limbs, tremors, and impaired balance and coordination.
Mutations in the SNCB gene lead to the production of a protein with impaired function. It is thought that this altered protein cannot effectively prevent alpha-synuclein accumulation. A decrease in functional beta-synuclein likely results in the formation of Lewy bodies—abnormal protein clusters that impair neuron function and ultimately cause cell death. Over time, the loss of neurons impairs intellectual and motor function and the regulation of emotions.
Other Names for This Gene
- beta-synuclein