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ICD-10 Code R65.11 - Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

Reviewed by Medicinsk Expert•Last updated: 2026-10-22•ICD Codes

ICD-10-CM Diagnosis Code R65.11

Diagnosis Code: R65.11 (Raw: R6511)

Description: Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

Classification: International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM)

Fiscal Year: 2026

CMS Section 111 Status: Valid for reporting.

Overview & Clinical Details

ICD-10-CM code R65.11 is designated for Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction. In medical documentation and insurance billing, this code is utilized to specify medical diagnosis for patient records, reimbursement workflows, and compliance under CMS Section 111 mandatory insurer reporting guidelines.

Source: MedlinePlus, National Library of Medicine

MedlinePlus brings together authoritative health information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), and other government agencies and health-related organizations.