ICD-10 Code D81.5 - Purine nucleoside phosphorylase [PNP] deficiency

ICD-10-CM Diagnosis Code D81.5

Diagnosis Code: D81.5 (Raw: D815)

Description: Purine nucleoside phosphorylase [PNP] deficiency

Classification: International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM)

Fiscal Year: 2026

CMS Section 111 Status: Valid for reporting.

Overview & Clinical Details

ICD-10-CM code D81.5 is designated for Purine nucleoside phosphorylase [PNP] deficiency. In medical documentation and insurance billing, this code is utilized to specify medical diagnosis for patient records, reimbursement workflows, and compliance under CMS Section 111 mandatory insurer reporting guidelines.